Compositions and methods for producing elevated and sustained ketosis

US Patent US 9138420 B2

Inventor: Dominic Paul D'Agostino, Patrick Arnold, Shannon Kesl
Current Assignee:  University of South Florida
Original Assignee: University of South Florida
Priority date:  2013-03-19


Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/L), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period of time. Further, use of these supplements to achieve ketosis yields a significant elevation of blood ketones and reduction of blood glucose levels. Use of these substances does not adversely affect lipid profiles. By initiating rapid ketosis and accelerating the rate of ketoadaptation, this invention is useful for the avoidance of glucose withdrawal symptoms commonly experienced by individuals initiating a ketogenic diet, and minimizes the loss of lean body mass during dietary restriction.


This invention was made with government support under Grant #N00014-13-1-0062 awarded by the Department of Defense, Office of Naval Research. The government has certain rights in the invention.


This invention relates to the use of ketogenic precursors to quickly produce elevated and sustained levels of ketone bodies in the blood and methods for assisting the body's transition into nutritional ketosis. Specifically, the use of a combination of medium chain triglycerides (MCT) with mineral salts of beta-hydroxybutyrate (βHB) is presented to provide an easy and accelerated method for inducing and sustaining nutritional ketosis.

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